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November 2015

Volume 1 Issue 2
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Editorial Perspective

The Music as a Therapy Integrated to Palliative Care of Patients with Cancer

Mustafa Levent, Ozgur Tanriverdi

The purpose of this paper is to show benefits of listening music and music therapy in supportive cancer care. Cancer is a chronic disease that has many complications such as vomiting, pain, anorexia and fear of death. Cancer also effects the patients’ social, economic and physical life. Music therapy is an alternative supplementary treatment for cancer patients. There are many benefits of music therapy.
  

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Editorial 

The Systems Biology Oriented, Holistic Vision of Personalized Medicine and The Emerging Concept of Proactive Herbal Medicine

Alessandro Buriani*, Stefano Fortinguerra

Application of –omics is rapidly growing in the clinic, providing a large number of clinically actionable information for clinical decisions. With new ability to analyze risk factors, a proactive, preventative and pre-emptive strategy may be used to sustain the individual’s health balance and proactively “normalize” pathogenetic dysfunctions, before a disease condition develops. This shift from a disease-oriented, reactive medical approach, to one that includes wellness-oriented proactivity is a potential game changer in many aspects of clinical practice.
  

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Research Article

Screening for HBsAg and HCV Antibodies among Military Personnel in the Niger Delta of Nigeria

Azuonwu Obioma, Erhabor Osaro*, Azuonwu Goodluck, Egenti Nonye

Despite the high job-related risk of exposure to sexually -transmitted diseases including HBV and HCV among the military, there is paucity of data regarding Hepatitis B and C viruses prevalence among military personnel in Nigeria. The aim of this present study therefore was to determine the prevalence of HBV and HCV among military personnel in the Niger Delta of Nigeria. In this cross-sectional case study, a total of One hundred and fifty military personnel aged 20 and 55 years attending the Nigerian Army Hospital, Air Force Clinic and Police Clinic in Port-Harcourt in the Niger Delta of Nigeria were consecutively recruited for the study.
  

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Case Report

Antiplatelet Pharmacogenomic Assessment in a Case of Coronary Artery Bypass

Stefano Fortinguerra, Gianfranco Varano, Alessandro Buriani*

If not contraindicated, it is reasonable to use DAPT, starting in the CABG postoperative period, using ASA in association with clopidogrel. There is no specific guideline indicating pharmacogenomic testing for DAPT, but the FDA recommends it when using clopidogrel. In the present case pharmacogenomics was used for the evaluation of DAPT one year after CABG. The results indicate that despite the platelet hyper-responsiveness to ADP, clopidogrel might not be indicated, due to an increased P-gp dependent intestinal efflux, and its use should be reconsidered to substitute it with a different drug, like ticlopidine, or to administer it concomitant with P-gp antagonists.
  

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Research Article

Prospective Investigation on The Significance of Carboxyhemoglobin Level in out-of-Hospital Cardiopulmonary Arrest

Yasumasa Oode MD, Hiromichi Ohsaka MD,PhD, Kouhei Ishikawa MD, Kei Jitsuiki MD, Mariko Obinata MD, Kentaro Mishima MD, Kazuhiko Omori MD,PhD, Yanagawa Youichi MD, Ph.D

Global cerebral ischemia-reperfusion injury induces the expression of Heme oxygenase 1 (HO-1). HO-1 is a ubiquitous inducible stress-response protein which serves a major metabolic function in heme turnover. HO-1 activity cleaves heme to form biliverdin-IXα, endogenous carbon monoxide (CO), and iron, which play a concerted role in cytoprotection against oxidative stress and in the modulation of cell proliferation and differentiation.
  

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Preliminary publication of dissertation Kerstin Schierghofer

Endoscopic Retrograde Cholangiopancreatography - Analysis of 543 Procedures at the Kreiskrankenhaus Schongau [Schongau Hospital] 2006-2011 and Comparison with Literature

Kerstin Schierghofer*, Andreas Eder, Ursula Gresser

Cholecystolithiasis occurs in about 66% of the elderly population over 70 years of age. More than 98% of bile duct disorders are caused by gallstones. 10 to 33% of patients with gallstone related symptoms suffer from choledocholithiasis. Patients with common bile duct stones suffer from a variety of symptoms such as cholestasis, pain, cholangitis or pancreatitis. In addition to common bile duct stones, there are other causes of biliary obstruction such as tumors or trauma. Via abdominal ultrasound, an acute cholecystitis and variations in the biliary tract such as bile duct expansion can be displayed.
  

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Case Report

An Unusual Case of Salmonella UTI in a Male Teen

Yuan Liu, Thomas Waller

Nontyphoid Salmonella (NTS) is the leading bacterial cause of gastrointestinal infection globally and in the US. More than 90% of NTS infections are foodborne. NTS mostly causes acute self-limited colitis; bacteremia may develop in hosts with predisposing factors or with certain invasive serovars; focal disease may ensue due to immunosuppression and/or structural defects. Hydration is usually sufficient for colitis. Antibiotics are reserved for those who are immunocompromised, bacteremic, or at risk for severe focal disease. We will share an unusual case of NTS urinary tract infection in an apparently healthy male teen, and our reflections on the universal, diverse, and potentially fatal NTS infection.

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Research Article

Assessment of Antioxidant Micronutrients Levels in HIV/AIDS Patients in Sokoto, North Western Nigeria

Yeldu* MH, Mainasara AS, Dallatu M.K, Sani B, Bilbis LS, Njoku C.H, Das S.C.

Infection with human immunodeficiency virus (HIV) is associated with a decline in immunity or the inability to fight infection and progresses to acquired immunodeficiency syndrome (AIDS). Several studies have shown that, deficiencies of serum antioxidant vitamins (A, C and E)) and mineral elements (Copper,  Manganese, Selenium and Zinc) are common among HIVinfected persons, especially those in developing countries, and injection drug users. Thus a vicious cycle has been envisaged in which undernourished HIV- infected persons have micronutrient deficiencies, leading to further immune-suppression and oxidative stress and subsequent acceleration of HIV replication and CD4+ T-cell depletion.

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