Volume 1 Issue 1
Incidence of Hypertension in Coronary Artery Disease Patients in Eastern Province Saudi Arabia
Emad Ali Saleh AL-Khoufi*
The prevalence of coronary artery disease in Saudi Arabia is around 6% while the prevalence of hypertension is 26 % in general population. Epidemiological studies suggest a strong and consistent link between hypertension and coronary artery disease. This does not mean that hypertension is the cause of coronary artery disease. Less than a quarter of the risk of developing coronary artery disease can be attributed to raised blood pressure.
The Genetics of Inflammatory Bowel Disease
Ruijun Bao, MD, MS, Lijiang Ma, MD, PhD*
Inflammatory bowel disease (IBD) is considered as genetic disease due to observation of familial clustering of cases, genetic anticipation between generations and phenotypic concordance of some clinical features within families. Current knowledge of genes/loci associated IBD was largely developed by genome wide association studies which is common disease-common variant analysis strategy. With heterogeneity character and disease incidence of 4.75/100,000/year for Crohn’s disease and 2.06/100,000/year for ulcerative colitis in pediatric population, targeted resequencing and whole exome sequencing for the identification of rare pathogenic variants in known or novel genes are becoming more applicable for IBD genetic studies.
Interferon Side Effects: When Somatization Betrays You - A Case Report
Vital Da Silva Domingues*, Sara Neves, Margarida França
Neuropsychiatric symptoms are widely reported in association with both hepatitis C and IFNα treatment its sequelae, and its treatment. In particular, interferon, a primary component of treatment for chronic hepatitis C, has been strongly associated with depressive symptoms. This review summarizes current knowledge about the etiology, course, and treatment of neuropsychiatric problems associated with hepatitis C and interferon alpha (IFN-alpha and lead to discontinuation of interferon in up to 13% of cases.
Analysis of Clinical Characters of Cantu Syndrome: Etiology and High Penetrance of Cardiovascular Phenotypes
Lijiang Ma, MD, PhD*, Ruijun Bao, MD, MS
Cantu syndrome, also called hypertrichotic osteochondrodysplasia, is a rare congenital systemic disease which was first recognized in Mexico in 1982. More cases were reported to further delineate this genetic syndrome. Clinical manifestations were varied and the disease has been mistaken for acromegaloid facial appearance syndrome, hypertrichosis with acromegaloid facial appearance syndrome, or hypothyroidism.
Risk Factors of Esophageal Squamous Cell Cancer in Southwestern Uganda: A Case-Control Study
Samson Okello, MB chB, MMED*,Cristina Churchill, MD, Rogers Owori, MB chB, Benson Nasasira, MB chB, Christine Tumuhimbise, EN, Charles Lagoro Abonga, MB chB, David Mutiibwa, MB chB, MMED, Kathleen E Corey MD, MPH, MMSc
Despite a well described increase in adenocarcinoma, esophageal squamous cell carcinoma (ESCC) remains the predominant type of esophageal cancer worldwide. In sub-Saharan Africa, incidence of esophageal cancer has regional variation with southern and eastern regions reporting significantly higher incidence rates. Even within regions, there are within country variations. These variations may be due to differences in risk factor profiles. In East African men, esophageal cancer is the second most commonly diagnosed cancer and the second highest cause of cancer deaths.